| Date | Opponent | Home/Away | KO | Result | Scorer(s) |
| 2/8/2020 | Boltonian Ladies | Away | 2pm | 1-4 | Redford |
| 16/8/2020 | Nelson Ladies | Away | 2pm | 0-4 | |
| 2/9/2020 | BRNESC Ladies | Away | 6:15pm | 5-5 | Bibby (2), Norcross, Ross, Brookfield |
| 6/9/2020 | Liverpool Feds Development | Home (Played at the PURE Stadium) | 2pm | 8-2 | Brookfield (3), Norcross (2), Hassall, Ross, Davies |
| 20/9/2020 | BRNESC Ladies | Away | 2pm | 4-1 | Ashe-Wright (2), Bibby, Norcross |
| 27/9/2020 | Tranmere Rovers Ladies Reserves | Home | 2pm | 2-4 | Ashe-Wright, Norcross (pen) |
| 11/10/2020 | Ashton Town Ladies | Home | 2pm | ||
| 18/10/2020 | Alder Ladies | Away | 2pm | ||
| 25/10/2020 | Wirral Phoenix Ladies | Home | 2pm | ||
| 1/11/2020 | Pilkington Ladies | Away | 1pm | ||
| 8/11/2020 | NO GAME | ||||
| 15/11/2020 | MSB Woolton Ladies | Home | 2pm | ||
| 22/11/2020 | BRNESC Ladies | Home | 2pm | ||
| 29/11/2020 | Tranmere Rovers Ladies Reserves | Away | 2pm | ||
| 6/12/2020 | Marine FC Women | Home | 2pm | ||
| 17/1/2021 | Alder Ladies | Home | 2pm | ||
| 24/1/2021 | Ashton Town Ladies | Away | 2pm | ||
| 31/1/2021 | Wirral Phoenix Ladies | Away | 2pm | ||
| 7/2/2021 | Pilkington Ladies | Home | 2pm | ||
| 14/2/2021 | NO GAME | ||||
| 21/2/2021 | MSB Woolton Ladies | Away | 3:30pm | ||
| 28/2/2021 | Marine FC Women | Away | 3pm |
| Squad Number | Player Name | Position | 20/21 Appearances | 20/21 Goals |
| 1 | Tamika Hunter-Barnett | Goalkeeper | 2 | 0 |
| 2 | Tanya Leedham | Defender/Midfield | 2 | 0 |
| 3 | Jessica Grimes | Midfield | 0 | 0 |
| 4 | Natasha Leadbetter | Defender/Midfield | 2 | 0 |
| 5 | Alexandra Capp | Defender | 2 | 0 |
| 6 | Rebecca Redford | Midfield/Defender | 2 | 0 |
| 7 | Sophie Birnie | Midfield | 2 | 0 |
| 8 | Georgia Davies | Midfield | 1 | 0 |
| 9 | Jessica Hassall | Striker | 1 | 0 |
| 10 | Hannah Brookfield | Midfield/Striker | 2 | 0 |
| 11 | Sophie Speariett | Defender/Midfield/Striker | 1 | 0 |
| 12 | Tessa Bruce | Defender/Midfield | 0 | 0 |
| 13 | Eva Boyle | Goalkeeper | 0 | 0 |
| 14 | Megan Hyland | Midfield | 0 | 0 |
| 15 | Hayley Sharrock | Defender/Midfield | 2 | 0 |
| 16 | Kara Gregory | Defender/Midfield | 1 | 0 |
| 17 | Emily Norcross | Midfield | 2 | 2 |
| 18 | Megan Birchall | Defender | 2 | 0 |
| 19 | Jessica Ashe-Wright | Defender/Midfield/Striker | 2 | 3 |
| 20 | Charlotte Ross | Striker | 2 | 0 |
| 21 | Laura Ashcroft | Defender/Midfield | 0 | 0 |
| 22 | Gayna Eeles | Defender | 0 | 0 |
| 23 | Ashleigh Bibby | Striker | 2 | 1 |
| 24 | Katie Edwards | Defender | 1 | 0 |
| 25 | Elisabeth Nilsen Halvorsen | Striker | 0 | 0 |