Updated 12 May
| Date | Opponent | Home/Away | KO | Result | Scorer(s) |
| 2/8/2020 | Boltonian Ladies (Friendly) | Away | 2pm | 1-4 | Redford |
| 16/8/2020 | Nelson Ladies (Friendly) | Away | 2pm | 0-4 | |
| 2/9/2020 | BRNESC Ladies (Friendly) | Away | 6:15pm | 5-5 | Bibby (2), Norcross, Ross, Brookfield |
| 6/9/2020 | Liverpool Feds Development (Friendly) | Home (Played at the PURE Stadium) | 2pm | 8-2 | Brookfield (3), Norcross (2), Hassall, Ross, Davies |
| 20/9/2020 | BRNESC Ladies | Away | 2pm | 4-1 | Ashe-Wright (2), Bibby, Norcross |
| 27/9/2020 | Tranmere Rovers Ladies Reserves | Home | 2pm | 2-4 | Ashe-Wright, Norcross (pen) |
| 11/4/2021 | Ashton Town Ladies | Home | 2pm | 3-0 | Bibby, Norcross, Birnie |
| 18/4/2021 | Tranmere Rovers Ladies Reserves | Away | 2pm | 1-2 | Brookfield |
| 20/4/2021 | Marine FC Women | Home | 7pm | 2-3* | Brookfield, Norcross |
| 25/4/2021 | Alder FC Women | Home | 2pm | 3-4 | Ross, Brookfield, Davies |
| 2/5/2021 | Wirral Phoenix Ladies | Home | 2pm | 6-3 | Norcross, Ashe-Wright, Davies, Brookfield, Ashcroft, Birnie |
| 9/5/2021 | Ashton Town Ladies | Away | 2:30pm | 6-4 | Davies, Brookfield, Birnie (2), Hassall (2) |
| 11/5/2021 | BRNESC Ladies | Home | 6:45pm | 4-3 | Brookfield, Redford (pen), Ross, Ashe-Wright |
| 16/5/2021 | Alder FC Women | Away | 2pm | ||
| 23/5/2021 | Marine FC Women | Away | 2pm | ||
| 26/5/2021** | MSB Woolton Ladies | Away | TBC | ||
| 30/5/2021 | MSB Woolton Ladies | Home | 2pm | ||
| 6/6/2021 | Pilkington Ladies | Home | 2pm | ||
| 9/6/2021** | Pilkington Ladies | Away | TBC | ||
| 13/6/2021 | Wirral Phoenix Ladies | Away | 2pm |
*Game subsequently awarded as a win to SFC Women due to opposition fielding ineligible players.
**Dates and Times of midweek fixtures to be confirmed.
| Squad Number | Player Name | Position | 20/21 Appearances | 20/21 Goals |
| 1 | Tamika Hunter-Barnett | Goalkeeper | 8 | 0 |
| 2 | Tanya Leedham | Defender/Midfield | 2 | 0 |
| 3 | Jessica Grimes | Midfield | 0 | 0 |
| 4 | Natasha Leadbetter | Defender/Midfield | 4 | 0 |
| 5 | Alexandra Capp | Defender | 2 | 0 |
| 6 | Rebecca Redford | Midfield/Defender | 9 | 1 |
| 7 | Sophie Birnie | Midfield | 9 | 4 |
| 8 | Georgia Davies | Midfield | 8 | 3 |
| 9 | Jessica Hassall | Striker | 7 | 2 |
| 10 | Hannah Brookfield | Midfield/Striker | 9 | 6 |
| 11 | Sophie Speariett | Defender/Midfield/Striker | 7 | 0 |
| 12 | Tessa Bruce | Defender/Midfield | 0 | 0 |
| 14 | Megan Hyland | Midfield | 0 | 0 |
| 15 | Hayley Sharrock | Defender/Midfield | 8 | 0 |
| 16 | Kara Gregory | Defender/Midfield | 6 | 0 |
| 17 | Emily Norcross | Midfield | 9 | 5 |
| 18 | Megan Birchall | Defender | 2 | 0 |
| 19 | Jessica Ashe-Wright | Defender/Midfield/Striker | 9 | 5 |
| 20 | Charlotte Ross | Striker | 6 | 2 |
| 21 | Laura Ashcroft | Defender/Midfield | 6 | 1 |
| 22 | Gayna Eeles | Defender | 0 | 0 |
| 23 | Ashleigh Bibby | Striker | 3 | 2 |
| 24 | Katie Edwards | Defender | 8 | 0 |
| 25 | Elisabeth Nilsen Halvorsen | Striker | 0 | 0 |
| 26 | Nicole Power | Midfield | 2 | 0 |
| 31 | Eva Boyle | Goalkeeper | 5 | 0 |